Offered diazepam's storied record as being a usually utilized and effective medication for a range of indications, modern enhancements within the formulation and administration with the agent consist of the event and US FDA approval of an car-injectable formulation for the immediate cure of uncontrolled seizures in 2015-2016 7.
miconazole vaginal will raise the amount or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
dasatinib will improve the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
acetazolamide will improve the stage or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.
Stay clear of concomitant use of tucatinib with CYP3A substrates, the place negligible focus variations may perhaps cause major or existence-threatening toxicities. If unavoidable, lessen CYP3A substrate dose Based on merchandise labeling.
ceritinib will improve the degree or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
diazepam will improve the level or outcome of avapritinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
diazepam decreases amounts of acetaminophen rectal by expanding metabolism. Insignificant/Significance Mysterious. Increased metabolism incr amounts of hepatotoxic metabolites.
diazepam raises amounts of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Lomitapide dose shouldn't exceed 30 mg/day.
Diazepam may perhaps interfere with metabolism of substrates for CYP2C19 and CYP3A4 bringing about a possible drug-drug interaction
hydrocortisone will lower the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
artemether/lumefantrine will lower the level or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
diazepam will enhance the amount or outcome of tazemetostat by impacting hepatic/intestinal enzyme more info CYP3A4 metabolism. Use Warning/Monitor.
The period of hypnotic effect along with the profile of undesirable adverse outcomes could possibly be motivated via the distribution and elimination half-life of your administered temazepam and any Lively metabolites Which may be formed 13. When these kinds of half-life are extended, the drug or its metabolite(s) may perhaps accumulate through intervals of nightly administration and be associated with impairments of cognitive and motor performance for the duration of waking several hours 13.